NeuroTechnologies
NeuroTechnologies (NeuroTech)
The BME M2 NeuroTech track aims to train scientists, engineers, and medical practitioners in the fundamentals of neuronal engineering, equipping them for applications in academic research, industry, medical research, clinical practice, and societal innovations.
Key Objectives
- Bridge the gap for students with backgrounds in engineering, mathematics, and physics, enabling them to apply their knowledge to neurosciences and technological advancements.
- Offer specialized training for biomedical sciences students focused on neuronal technologies and their applications.
- Provide medical students and interns with the technological expertise necessary for advancements in neurological and mental health care.
The NeuroTech track is an integral part of the broader biomedical engineering master’s program, interconnected with other tracks, and focused on specialized technologies and applications within the neural domain.
Audience
- Students with backgrounds in biomedical sciences.
- Students from engineering schools.
- Students and interns in health sciences (medicine, pharmacy, physiotherapy, etc.).
Motivation
With the increasing availability and power of neuronal technologies, the NeuroTech track addresses the growing need to understand the brain, monitor and diagnose health conditions, prevent or treat neural and mental disorders, restore neurological functions, and facilitate communication and interaction with the nervous system. These technologies have diverse applications, primarily in healthcare, but also extend to key industrial sectors such as transportation, machinery, and robotics, as well as the emerging leisure industry. There is a significant demand for engineers, scientists, and health practitioners trained in neural technologies, with a strong emphasis on health-related applications, while also encompassing other fields of interest
Overview of the Program’s Structure
The program is designed for biomedical and engineering students, while a dedicated sub-track with an adapted curriculum is proposed for medical and other health science students.
Neurotechnologies for health applications involve three fundamental domains of training for any neural engineering graduate:
- Knowledge about the brain, nervous systems, and the functions they ensure.
- Understanding of neurological and mental disorders and diseases through the lens of neuroscience.
- Expertise in technologies used to investigate the nervous system and interact with it.
This core program includes mandatory courses on neurosciences, health, and neural engineering, providing the foundations for a neuro-engineering seminar that explores state-of-the-art applications. The mandatory curriculum also includes transdisciplinary projects in biomedical engineering innovation and an ethics workshop, which is transversal with the other tracks of the master’s program. Students can further specialize through optional courses.
Targeted Professional Domains for Graduates
- Academic research : PhD
- Neurology and mental health practice and research (medical students)
- Translational research
- Industry:
- Research and development
- Clinical research
- Innovation and technological transfer
- Business development
- Start-ups
Courses
Courses are structured into 3 or 6 ECTS Teaching Units T.U, where 3 ECTS counts for with maximum 25 hours of presence time of students and an estimated 60 hours of additional personal work. 30 ECTS are required to validate a semester
Semester 3
Mandatory courses (24 ECTS)
Course Title: Interdisciplinary week
Description:
Key words:
Total number of hours: Number of ECTS: Semester
Mandatory course ☐ Optional course ☐
Prerequisites/skills needed:
Teaching methods and activities:
Location:
Course supervisor:
Course Title: Neuroscience Refresher/Primer
Description: These courses aim at: – providing the basic biological notions required for engineering students to follow the BIN track, while refreshing and/or complementing knowledge previously acquired by science and medical students – encouraging collaborative mutualization of knowledge between the students from different background.
Key words: neuroanatomy, nerve signals, neuronal networks, brain development
Total number of hours: 22 Number of ECTS: 3 Semester 3
Mandatory course ☒ Optional course ☐
Prerequisites/skills needed: Engineering students are advised to prepare for the course by reading the introductory chapters of neuroscience textbooks (e.g. “Fundamental Neuroscience” by Kandel et al, or “Neuroscience” by Purves et al, and “Neuroanatomy” by Crossman & Neary)
Teaching methods and activities: lectures (CM), practical sessions (TD)
Location: université paris cité, Campus Saint-Germain-des-Prés
Course supervisor: Claude Meunier (researcher)
Course Title: A window into the mind : new technologies to explore and stimulate the brain
Description: This UE presents the following topics as 2- to 3h lectures : Overview of the neurophysiological mechanisms related to the different methods of exploration of brain activity – Principles of experimental research in Neuroscience – Exploration of Brain activity: Basic concepts and description of intracranial recordings in behaving animals and optogenetics – Non-invasive exploration and stimulation in human brain: fIRM and TMS – Acoustical brain imaging: from observation to treatment – Optogenetics and machine learning in Neuroscience – Brain imaging with voltage-sensitive dyes – Two-photon microscopy introduction and new evolution: Fast multisite optical recordings with acousto-optic deflectors. The UE also includes one day devoted to presentations of scientific papers by students in front of the class.
Key words: Brain imaging, optogenetics, ultrasound
Total number of hours: 29 Number of ECTS: 3 Semester 3
Mandatory course ☒ Optional course ☒
Prerequisites/skills needed: Some basic neuroscience (cf UE Refresher courses), notions in frequency analysis
Teaching methods and activities: Lectures (CM), other: article presentations by students
Location: ESPCI Paris
Course supervisor: Karim BENCHENANE (researcher)
Course Title: Sensory Supplementation
Description: Sensory supplementation systems for audition, vision, proprioception, gaze and postural control consist of supplying individuals with additional artificial information about sensory information and motion to substitute or supplement the natural visual, auditory, somatosensory and vestibular sensory cues. The aim of this course is to present the concept of the human sensory supplementation. These kinds of supplements have a large range of applications, from medicine to sport and military developments. The various supplements allowing the improvement of the sensory capacities of the human body will be presented and discussed: artificial retinae, vibrotactile prostheses, cochlear implant, cochlear prostheses and vestibular implants.
Key words: Sensorimotor transformation, prosthesis, rehabilitation
Total number of hours: 24 Number of ECTS: 3 Semester 1 and 2
Mandatory course ☒ Optional course ☐
Prerequisites/skills needed: Minimal understanding of the basic mathematical concepts (kinematics, dynamics, Fourier analysis) and of the physiological concepts (basic anatomy and sensory physiology).
Teaching methods and activities: Lectures (CM), other: visits of clinical departments and research groups related to the topics of the courses
Location: université paris cité, Campus Saint-Germain-des-Prés
Course supervisor: Catherine VIDAL (MD-PhD)
Course Title: Motor supplementation and Human Machine Interface
Description:
The aim of this course is twofold.
Firstly, it will present the concept of the human motor supplementation. These kinds of supplements have a large range of applications, from medicine to military developments. The various supplements allowing the improvement of motor capacities of the human body will be presented and discussed: exoskeletons, cognitive robotics, tele-robotics (force-feedback control), orthosis and prosthesis, trans and intra-cranial electrical stimulation, robots for the assistance or for the rehabilitation to walking and grasping.
In addition, Human-Machine Interface has emerged as a key issue for complex systems requiring human operators, mainly due to increased safety at the technical level. Aviation is an exemplary applied field for this statement. As such, the second aim of this course is to browse current human adaptability and limits to understanding, and to expand this approach by dwelling into the question of human behavior quantization. Several applied topics, including simulation, sensor fusion, biomedical monitoring in extreme environments and high-level sport will be used to present state-of-the-art measurement paradigms. The ubiquitous issue of cognitive workload, situation awareness and high-level performance will be presented. Elements of systemic and collective aspects will also be discussed.
Key words: Motor control, BCI, Human factor, Simulator, Interface
Total number of hours: 18 Number of ECTS: 3 Semester 3
Mandatory course ☒ Optional course ☐
Prerequisites/skills needed: Some notions acquired from UE Sensory supplementation
Teaching methods and activities: Lectures (CM)
Location: université paris cité, Campus Saint-Germain-des-Prés
Course supervisor: Stéphane BUFFAT (MD-PhD)
Course Title: Detection of Vigilance States and Communication with the Environment
Description: The aim of this course is to provide students with the different concepts of detection and modulation of vigilance conditions. The influence of the different vigilance states and specially “hypovigilance” on human neuro-sensorials responses will be developed. Various clinical situations of non communicating subjects for whom it is crucial to detect and improve vigilance or consciousness condition will be explored such as during prolonged coma and in wholly paralyzed but conscious subjects. We will examine also new methodologies to improve communication with a severely handicapped subject and the issue of cerebral death. This course is based on theoretical and on practical work sessions and/or on mini projects.
Key words: Vigilance, consciousness, neurological disorders, stroke, traumatic brain injury
Total number of hours: 20 Number of ECTS: 3 Semester 3 and 4
Mandatory course ☒ Optional course ☐
Prerequisites/skills needed: Minimal understanding of the basic mathematical concepts (kinematics, dynamics, Fourier analysis) and of the physiological concepts (basic anatomy and sensory physiology)
Teaching methods and activities: Lectures (CM), other: visits of clinical departments and robotic lab for disabled people
Location: université paris cité, Campus Saint-Germain-des-Prés
Course supervisor: Alexis Schnitzler (PU-PH)
Semester 4
Mandatory courses (30 ECTS)
Course Title: Business Plan Workshop
Description: This 1-week workshop will teach how to manage, as a team, the creation of an innovative company (start-up). It will illustrate all aspects of project building, up to a Business plan and its oral presentation. Students will be coached by professionals throughout the workshop. Biomedical entrepreneurs and venture capital experts will be invited to share their hands-on experience. The objectives of the workshop are: – increasing the autonomy of the students – teaching them how to take risks – teaching them how to work responsibly and coherently as a team – providing them with the necessary economic concepts and practical tools.
Key words: entrepreneurship, business model, start-up, innovation, venture capital
Total number of hours: 35 Number of ECTS: 3 Semester 4
Mandatory course ☒ Optional course ☐
No prerequisite
Teaching methods and activities: lectures (CM), practical sessions (TD), teamwork
Location: Arts et Métiers ParisTech or ESPCI Paris
Course supervisor: Catherine LEGER-JARNIOU (Professor), André KLARSFELD (Professor)
Course Title: Research Internship
Description: Students are encouraged to write a 5-year plan and discuss it with track chairs before contacting labs for internships, so they have a clear idea of what would suit their aspirations best, e.g. a clinical lab or project might be more appropriate for a student aiming for medical school (“passerelle”). An exhaustive list of labs/institutions, as well as specific projects received from lab heads, may be suggested to students looking for internship positions. A student’s final choice MUST be validated by track chairs. They will evaluate the proposed internship project mainly according to its adequacy to the student’s skills and objectives, its scientific quality, the lab/team record and the number of M2 students it will be hosting during the same period. The student’s work will be evaluated from an oral defense in front of a jury (50%) and a written report (50%).
Total number of hours: 5-6 months full time Number of ECTS: 26 Semester 4
Mandatory course ☒ Optional course ☐
Prerequisites/skills needed: UE Methodology provides some useful notions
Teaching methods and activities: mentoring by internship supervisor(s)
Exact location: An academic, industrial or clinical lab validated by track chairs
Course supervisors: André KLARSFELD (Professor), Pierre-Paul VIDAL (MD-PhD)
Elective courses during the Semester 3
Students are required to select two elective 3 ECTS courses from the following options. Two predefined combinations ensure compatibility in terms of content and scheduling. The first combination, focusing on « Neuro-Imaging and Models, » consists of the courses « Neuroimaging » and « Biological Models in Neuroscience. » The second combination, exploring « Neuro Control and Sensory-Motricity, » includes the courses « Digital Technologies for Neurosciences » and « Neural Control of Posture and Motricity. » In addition to these two guaranteed combinations, students can also opt for other pairings that meet schedule compatibility requirements. This may include one external course, pending acceptance. Elective course selections must be made during the application process and confirmed following the admission interview.
Course Title: Detection of Vigilance States and Communication with the Environment
Description: The aim of this course is to provide students with the different concepts of detection and modulation of vigilance conditions. The influence of the different vigilance states and specially “hypovigilance” on human neuro-sensorials responses will be developed. Various clinical situations of non communicating subjects for whom it is crucial to detect and improve vigilance or consciousness condition will be explored such as during prolonged coma and in wholly paralyzed but conscious subjects. We will examine also new methodologies to improve communication with a severely handicapped subject and the issue of cerebral death. This course is based on theoretical and on practical work sessions and/or on mini projects.
Key words: Vigilance, consciousness, neurological disorders, stroke, traumatic brain injury
Total number of hours: 20 Number of ECTS: 3 Semester 3 and 4
Mandatory course ☒ Optional course ☐
Prerequisites/skills needed: Minimal understanding of the basic mathematical concepts (kinematics, dynamics, Fourier analysis) and of the physiological concepts (basic anatomy and sensory physiology)
Teaching methods and activities: Lectures (CM), other: visits of clinical departments and robotic lab for disabled people
Location: université paris cité, Campus Saint-Germain-des-Prés
Course supervisor: Alexis Schnitzler (PU-PH)
Course Title: Detection of Vigilance States and Communication with the Environment
Description: The aim of this course is to provide students with the different concepts of detection and modulation of vigilance conditions. The influence of the different vigilance states and specially “hypovigilance” on human neuro-sensorials responses will be developed. Various clinical situations of non communicating subjects for whom it is crucial to detect and improve vigilance or consciousness condition will be explored such as during prolonged coma and in wholly paralyzed but conscious subjects. We will examine also new methodologies to improve communication with a severely handicapped subject and the issue of cerebral death. This course is based on theoretical and on practical work sessions and/or on mini projects.
Key words: Vigilance, consciousness, neurological disorders, stroke, traumatic brain injury
Total number of hours: 20 Number of ECTS: 3 Semester 3 and 4
Mandatory course ☒ Optional course ☐
Prerequisites/skills needed: Minimal understanding of the basic mathematical concepts (kinematics, dynamics, Fourier analysis) and of the physiological concepts (basic anatomy and sensory physiology)
Teaching methods and activities: Lectures (CM), other: visits of clinical departments and robotic lab for disabled people
Location: université paris cité, Campus Saint-Germain-des-Prés
Course supervisor: Alexis Schnitzler (PU-PH)
Course Title: Detection of Vigilance States and Communication with the Environment
Description: The aim of this course is to provide students with the different concepts of detection and modulation of vigilance conditions. The influence of the different vigilance states and specially “hypovigilance” on human neuro-sensorials responses will be developed. Various clinical situations of non communicating subjects for whom it is crucial to detect and improve vigilance or consciousness condition will be explored such as during prolonged coma and in wholly paralyzed but conscious subjects. We will examine also new methodologies to improve communication with a severely handicapped subject and the issue of cerebral death. This course is based on theoretical and on practical work sessions and/or on mini projects.
Key words: Vigilance, consciousness, neurological disorders, stroke, traumatic brain injury
Total number of hours: 20 Number of ECTS: 3 Semester 3 and 4
Mandatory course ☒ Optional course ☐
Prerequisites/skills needed: Minimal understanding of the basic mathematical concepts (kinematics, dynamics, Fourier analysis) and of the physiological concepts (basic anatomy and sensory physiology)
Teaching methods and activities: Lectures (CM), other: visits of clinical departments and robotic lab for disabled people
Location: université paris cité, Campus Saint-Germain-des-Prés
Course supervisor: Alexis Schnitzler (PU-PH)
Course Title: Detection of Vigilance States and Communication with the Environment
Description: The aim of this course is to provide students with the different concepts of detection and modulation of vigilance conditions. The influence of the different vigilance states and specially “hypovigilance” on human neuro-sensorials responses will be developed. Various clinical situations of non communicating subjects for whom it is crucial to detect and improve vigilance or consciousness condition will be explored such as during prolonged coma and in wholly paralyzed but conscious subjects. We will examine also new methodologies to improve communication with a severely handicapped subject and the issue of cerebral death. This course is based on theoretical and on practical work sessions and/or on mini projects.
Key words: Vigilance, consciousness, neurological disorders, stroke, traumatic brain injury
Total number of hours: 20 Number of ECTS: 3 Semester 3 and 4
Mandatory course ☒ Optional course ☐
Prerequisites/skills needed: Minimal understanding of the basic mathematical concepts (kinematics, dynamics, Fourier analysis) and of the physiological concepts (basic anatomy and sensory physiology)
Teaching methods and activities: Lectures (CM), other: visits of clinical departments and robotic lab for disabled people
Location: université paris cité, Campus Saint-Germain-des-Prés
Course supervisor: Alexis Schnitzler (PU-PH)
Course Title: Detection of Vigilance States and Communication with the Environment
Description: The aim of this course is to provide students with the different concepts of detection and modulation of vigilance conditions. The influence of the different vigilance states and specially “hypovigilance” on human neuro-sensorials responses will be developed. Various clinical situations of non communicating subjects for whom it is crucial to detect and improve vigilance or consciousness condition will be explored such as during prolonged coma and in wholly paralyzed but conscious subjects. We will examine also new methodologies to improve communication with a severely handicapped subject and the issue of cerebral death. This course is based on theoretical and on practical work sessions and/or on mini projects.
Key words: Vigilance, consciousness, neurological disorders, stroke, traumatic brain injury
Total number of hours: 20 Number of ECTS: 3 Semester 3 and 4
Mandatory course ☒ Optional course ☐
Prerequisites/skills needed: Minimal understanding of the basic mathematical concepts (kinematics, dynamics, Fourier analysis) and of the physiological concepts (basic anatomy and sensory physiology)
Teaching methods and activities: Lectures (CM), other: visits of clinical departments and robotic lab for disabled people
Location: université paris cité, Campus Saint-Germain-des-Prés
Course supervisor: Alexis Schnitzler (PU-PH)
Courses presentations
NeuroTech Mandatory Courses
I. Foundations in Neurosciences (6 ECTS)
This course provides the scientific bases necessary for technological approaches to health issues in neurology and mental health. It is divided into two parts:
The Brain and the Nervous System: Covers the structure and physiology of the central and peripheral nervous systems, and the spinal cord at all scales. Topics include neuroanatomy, neural cells, neurotransmission, and action potentials.
Brain Functions: Discusses the sensory and motor systems, speech, cognition, vigilance, memory and learning, and social interactions.
II. Foundations of Neural and Mental Health (3 ECTS)
This course provides fundamental knowledge on major classes of neurological and mental disorders. It also introduces non-medical students to the realities of patient interactions, issues, and expectations for neuronal engineering contributions to diagnosis, treatment, rehabilitation, and prevention.
III. Foundations in Neuroengineering (6 ECTS)
This course covers the fundamental technologies for neurosciences and involving the nervous system. It is divided into three parts:
Monitoring and Recording in Neurosciences: Observing and recording the nervous system, monitoring, and recording behavior and physiological data.
- Data, Signal Processing, and Analysis for Neurosciences: Covers signals, images, filtering, feature extraction, and the fundamentals of machine learning and AI.
Stimulating and Interfacing with the Nervous System: Fundamentals in BCI (Brain-Computer Interfaces), Deep Brain Stimulation, and Neuroprosthetics.
IV. Advanced Topics in Neurotechnology (3 ECTS)
A seminar-style course that covers the latest research and developments in neurotechnology. Students will engage with cutting-edge topics through readings, presentations, and discussions, fostering a deep understanding of current trends and future directions in the field.Topics include sensory and motor supplementation, deep brain stimulation, neurofeedback, diagnostic systems, neuro-inspired engineering, and sports. The course consists of seminars and debates presented and prepared by students under the supervision of research staff.
NeuroTech Mandatory Transversal Courses
I. Interdisciplinary Biomedical Seminar (3 ECTS)
This project is conducted in collaboration with the other BME master’s tracks. Its aim is to train students in the development of research and development projects of biomedical interest. From the initial creative phase of imagining innovative approaches and ideas to the art of formulating sound scientific questions, students will learn to set up a research program that includes considerations of funding, ethical issues, and expected outcomes. Projects must integrate learning from the ethical workshop. Specific organization of this course still to be discussed as of October 2024.
II. Ethical, Industrial and Environmental aspects in biomedical engineering (3 ECTS)
This course addresses the ethical considerations and societal implications of biomedical engineering. Topics include patient consent, data privacy, the impact of neural technologies on society, and the ethical dilemmas faced by professionals in the field. Ethical considerations are of paramount importance for all biomedical applications, including research involving humans and animals and assessing societal and climate impact. This workshop, common to all tracks, trains students to be aware of the range of ethical issues and to develop appropriate responses during internships, PhD studies, and other professional activities. Specific organization of this course still to be discussed as of November 2024.
III Research Methodology (3 ECTS)
The course aims to equip master’s students in biomedical engineering with essential skills for conducting rigorous scientific research and generating both applied and fundamental knowledge. Research methodology encompasses a broad array of professional practices applicable across settings, from academic institutions to corporate research environments. It involves competencies in planning and executing research, analyzing data, validating hypotheses, and translating findings into publications and presentations for wide dissemination and application. The course is offered at two levels—basic and advanced. The basic level introduces fundamental statistical tools for quantitative research, emphasizing statistical hypothesis testing, with practical sessions. It also covers core principles of scientific writing and the publication process. The advanced level delves into machine learning, Bayesian approaches, advanced scientific writing, and publication strategies. Students will also develop skills in data visualization, data management, coding standards, and science communication, emphasizing open science and responsible research practices.
Elective (optional) courses
Two predefined elective combinations ensure schedule compatibility and allow students to focus on specific themes. The first combination, « Neuro-Imaging and Models, » combines « Neuroimaging » and « Biological Models in Neuroscience. » The second combination, « Neuro-Control and Sensory-Motricity, » pairs « Digital Technologies for Neurosciences » with « Neural Control of Posture and Motricity. » Students may also choose other elective combinations that align with the program’s schedule, pending time-table compatibility.
I Neuroimaging (3ECTS)
The course focuses on specialized digital signal processing and analysis for imaging, quantification of neuronal images, advanced imaging technologies, and visualization and analysis software. These courses aim to provide in-depth knowledge and skills in cutting-edge neuroimaging techniques.
II Biological models in neuroscience (3ECTS)
This course offers a comprehensive introduction to various technologies and research methods involving biological models in neuroscience. Topics include animal models, microfabrication and microfluidics, cell cultures, organoids, and emerging trends toward cybernetic models.
III Digital Technologies for Neurosciences (3 ECTS)
This course offers an exploration of advanced techniques and cutting-edge methods used to study and interact with the nervous system. It provides insights into technologies for monitoring and analyzing neural, behavioral and physiological data.
III Neural control of posture and motricity (3 ECTS)
This course explores the complex relationship between neural processing and biomechanics, focusing on how the nervous system regulates movement and balance. It covers the coordination of motor control, examines movement-related pathologies, and discusses advancements in neuroscience and biomechanics that aim to restore or enhance motor function. The course addresses both clinical and technological challenges in neuronal engineering, providing a comprehensive understanding of motor control mechanisms.